Open AccessPodocyte injury induced by mesangial-derived cytokines in IgA nephropathy
Author(s) -
K.N. Lai,
Joseph C.K. Leung,
Loretta Y.Y. Chan,
Moin A. Saleem,
P. W. Mathieson,
Ka Ying Tam,
Jing Xiao,
F M Lai,
Sydney C.W. Tang
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfn441
Subject(s) - nephrin , podocyte , podocin , synaptopodin , nephropathy , immunostaining , medicine , glomerulonephritis , podocalyxin , endocrinology , immunology , proteinuria , kidney , immunohistochemistry , diabetes mellitus
We have previously documented that human mesangial cell (HMC)-derived tumour necrosis factor-alpha (TNF-alpha) is an important mediator involved in the glomerulo-tubular communication in the development of interstitial damage in IgA nephropathy (IgAN). With the strategic position of podocytes, we further examined the function of podocytes in IgAN.
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