Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats | Zendy

William T. Noonan | Zendy; Kristin A. Koch | Zendy; Masaki Nakane | Zendy; Junli Ma | Zendy; Douglas B. Dixon | Zendy; Antoinette L. Bolin | Zendy; Gregory A. Reinhart | Zendy

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Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats

Author(s) -

William T. Noonan,

Kristin A. Koch,

Masaki Nakane,

Junli Ma,

Douglas B. Dixon,

Antoinette L. Bolin,

Gregory A. Reinhart

Publication year - 2008

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfn375

Subject(s) - medicine , calcification , pulse wave velocity , paricalcitol , pathogenesis , kidney disease , vitamin d and neurology , endocrinology , cardiology , aorta , calcitriol receptor , calcium , parathyroid hormone , secondary hyperparathyroidism , blood pressure

Vascular calcification is associated with an increase in cardiovascular mortality in stage 5 chronic kidney disease. To determine if vitamin D receptor activators (VDRAs) have differential effects in the pathogenesis of aortic calcification, we assessed the effects of paricalcitol and doxercalciferol in vivo using 5/6 nephrectomized (NX) rats. To quantify the functional consequences of vascular calcification, pulse wave velocity (PWV), an aortic compliance index, was measured.

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