Evaluation of parathyroid gland angiogenesis in chronic kidney disease associated with secondary hyperparathyroidism | Zendy

Pedro Martins | Zendy; Fernando Schmitt | Zendy; Henrique Almeida | Zendy; João Frazão | Zendy

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Evaluation of parathyroid gland angiogenesis in chronic kidney disease associated with secondary hyperparathyroidism

Author(s) -

Pedro Martins,

Fernando Schmitt,

Henrique Almeida,

João Frazão

Publication year - 2008

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfn150

Subject(s) - medicine , secondary hyperparathyroidism , angiogenesis , kidney disease , hyperplasia , vascular endothelial growth factor , hyperparathyroidism , parathyroid gland , parathyroidectomy , pathology , parathyroid hormone , immunohistochemistry , endocrinology , calcium , vegf receptors

Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease. Increased parathyroid hormone (PTH) synthesis and secretion is associated with parathyroid cell hyperplasia. The exact mechanisms involved in parathyroid gland (PTG) hyperplasia are still poorly understood. There is no available data on angiogenesis in PTG of patients with chronic kidney disease and SHPT. The aim of this study is to evaluate angiogenesis and expression of the angiogenic factors, basic fibroblastic growth factor (b-FGF) and vascular endothelial growth factor A (VEGF), in secondary PTG hyperplasia.

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