Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid | Zendy

Ekhlas Rahman | Zendy; Xiaoping Ruan | Zendy; Ravinder S. Chana | Zendy; Nigel J. Brunskill | Zendy; J.M. Gaya | Zendy; Stephen H. Powis | Zendy; Zac Varghese | Zendy; J.F. Moorhead | Zendy; David C. Wheeler | Zendy

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Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid

Author(s) -

Ekhlas Rahman,

Xiaoping Ruan,

Ravinder S. Chana,

Nigel J. Brunskill,

J.M. Gaya,

Stephen H. Powis,

Zac Varghese,

J.F. Moorhead,

David C. Wheeler

Publication year - 2008

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm901

Subject(s) - mesangium , scavenger receptor , medicine , monocyte , peripheral blood mononuclear cell , mesangial cell , macrophage , microbiology and biotechnology , receptor , immunology , intracellular , phenotype , matrix (chemical analysis) , glomerulonephritis , in vitro , kidney , biology , biochemistry , chemistry , cholesterol , lipoprotein , gene , chromatography

Monocyte recruitment into the mesangium and foam cell formation are recognized features of glomerular injury. External signals encountered by infiltrating mononuclear cells may determine their behaviour and thereby potentially influence disease outcome. Having previously demonstrated that monocytes are activated by exposure to matrix secreted by mesangial cells, we set out to determine whether matrix activation of monocytes led to expression of a macrophage phenotype.

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