Highly concentrated calcitriol and its analogues induce apoptosis of parathyroid cells and regression of the hyperplastic gland--study in rats | Zendy

Kazuhiro Shiizaki | Zendy; Ikuji Hatamura | Zendy; Shigeo Negi | Zendy; Takeshi Sakaguchi | Zendy; Fumie Saji | Zendy; Ikuo Imazeki | Zendy; Eiji Kusano | Zendy; Takashi Shigematsu | Zendy; Tadao Akizawa | Zendy

Open Access

Highly concentrated calcitriol and its analogues induce apoptosis of parathyroid cells and regression of the hyperplastic gland--study in rats

Author(s) -

Kazuhiro Shiizaki,

Ikuji Hatamura,

Shigeo Negi,

Takeshi Sakaguchi,

Fumie Saji,

Ikuo Imazeki,

Eiji Kusano,

Takashi Shigematsu,

Tadao Akizawa

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm850

Subject(s) - tunel assay , calcitriol , vitamin d and neurology , secondary hyperparathyroidism , hyperplasia , endocrinology , medicine , parathyroid gland , parathyroid hormone , apoptosis , hyperparathyroidism , parathyroid chief cell , ergocalciferol , calcitriol receptor , terminal deoxynucleotidyl transferase , calcium , chemistry , cholecalciferol , biochemistry , immunohistochemistry

Controlling hyperplasia of the parathyroid gland (PTG) is important in the management of secondary hyperparathyroidism (SHPT). Regression of the hyperplastic PTG requires a decrease in the number of parathyroid cells (PTCs), so the present study investigated cell death caused by toxic agents or by clinically usable vitamin D metabolites.

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