Open AccessEndothelial dysfunction in type-2 diabetics with early diabetic nephropathy is associated with low circulating adiponectin
Author(s) -
Mahmut İlker Yılmaz,
Mutlu Sağlam,
Abdul Rashid Qureshi,
Juan Jesús Carrero,
K. Çağlar,
Tayfun Eyıleten,
Alper Sönmez,
E. Çakır,
Y. Oğuz,
Abdülgaffar Vural,
Müjdat Yenicesu,
Peter Stenvinkel,
Bengt Lindholm,
John Axelsson
Publication year - 2008
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm828
Subject(s) - medicine , proteinuria , adiponectin , endocrinology , diabetic nephropathy , diabetes mellitus , type 2 diabetes , nephropathy , kidney disease , intima media thickness , endothelial dysfunction , gastroenterology , kidney , insulin resistance , carotid arteries
Type-2 diabetes and diabetic kidney disease have additive effects on cardiovascular risk. Furthermore, the degree of proteinuria is an independent predictor of mortality in this patient group. We hypothesized that altered kidney clearance and/or metabolism of vasoactive peptides occurring during proteinuria could link early diabetic nephropathy to cardio vascular disease (CVD).
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