In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats | Zendy

Giovambattista Capasso | Zendy; Chiara Iolanda Di Gennaro | Zendy; Fulvio Della Ragione | Zendy; Caterina Manna | Zendy; Roberto Ciarcia | Zendy; Salvatore Florio | Zendy; Alessandra Perna | Zendy; Rosa Maria Pollastro | Zendy; Sara Damiano | Zendy; Orazio Mazzoni | Zendy; Pierre M. Galletti | Zendy; Vincenzo Zappia | Zendy

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In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats

Author(s) -

Giovambattista Capasso,

Chiara Iolanda Di Gennaro,

Fulvio Della Ragione,

Caterina Manna,

Roberto Ciarcia,

Salvatore Florio,

Alessandra Perna,

Rosa Maria Pollastro,

Sara Damiano,

Orazio Mazzoni,

Pierre M. Galletti,

Vincenzo Zappia

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm784

Subject(s) - tbars , medicine , nephrotoxicity , oxidative stress , pharmacology , kidney , lipid peroxidation , renal function , antioxidant , endocrinology , biochemistry , chemistry

Cyclosporine A (CsA) is the first-line immunosuppressant used in transplant patients and in auto- immune diseases. Nephrotoxicity is the major limitation of CsA use. Although the mechanisms of nephrotoxicity have not been completely defined, some evidence suggests that reactive oxygen species (ROS) play a causal role. The present study was designed to investigate in vivo effects of hydroxytyrosol (DOPET), a natural olive oil antioxidant, on oxidative stress, renal histology and haemodynamic alterations induced in rats by CsA treatment.

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