Open AccessCarnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: studies in humans and in an animal model
Author(s) -
L Calò,
P. A Davis,
Elisa Pagnin,
L. Bertipaglia,
A Naso,
Antonio Piccoli,
R. Corradini,
Maurizio Spinello,
Vincenzo Savica,
Luciano Dalla Libera
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm707
Subject(s) - carnitine , erythropoietin , medicine , endocrinology , western blot , peripheral blood mononuclear cell , biochemistry , biology , in vitro , gene
Carnitine improves erythropoetin (EPO) response and anaemia in haemodialysis patients (HD); however, the mechanism(s) responsible remain unidentified. We have reported that carnitine induces haem oxygenase (HO)-1, which is an antioxidant and antiapoptotic that acts via pathways shared with EPO. Therefore carnitine's effect on these pathways may account for the improved EPO response. This study evaluates carnitine's effect on protein expression of HO-1 in unexplained EPO resistant HD. Carnitine's effect was assessed by HO-1 expression in patients and compared to its antiapoptotic effect via HO-1 induction in a rat model of carnitine-treated heart failure.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom