Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease | Zendy

Céline C. Berthier | Zendy; Patricia R. Wahl | Zendy; Michel Le Hir | Zendy; HansPeter Marti | Zendy; Ulrich Wagner | Zendy; Hubert Rehrauer | Zendy; Rudolf P. Wüthrich | Zendy; Andreas L. Serra | Zendy

Open Access

Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease

Author(s) -

Céline C. Berthier,

Patricia R. Wahl,

Michel Le Hir,

HansPeter Marti,

Ulrich Wagner,

Hubert Rehrauer,

Rudolf P. Wüthrich,

Andreas L. Serra

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm697

Subject(s) - medicine , matrix metalloproteinase , autosomal dominant polycystic kidney disease , sirolimus , polycystic kidney disease , polycystic kidney , kidney disease , disease , cancer research , pathology , endocrinology

Remodelling of matrix and tubular basement membranes (TBM) is a characteristic of polycystic kidney disease. We hypothesized that matrix and TBM degradation by metalloproteinases (MMPs) could promote cyst formation. We therefore investigated the renal expression of MMPs in the Han:SPRD rat model of autosomal dominant polycystic kidney disease (ADPKD) and examined the effect of sirolimus treatment on MMPs.

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