Open AccessInfluence of renal involvement on peripheral blood mononuclear cell expression behaviour of tumour necrosis factor- and interleukin-6 in type 2 diabetic patients
Author(s) -
Juan F. NavarroGonzález,
C. Mora,
M.A. Gómez,
Mercedes Muros,
Celeste López-Aguilar,
Javier Garcı́a Garcı́a
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm674
Subject(s) - medicine , microalbuminuria , endocrinology , peripheral blood mononuclear cell , diabetic nephropathy , diabetes mellitus , tumor necrosis factor alpha , urinary system , interleukin 6 , nephropathy , albuminuria , renal function , cytokine , biology , in vitro , biochemistry
Type 2 diabetes is associated with a high cardiovascular risk, which is even increased if renal damage is superimposed. Peripheral blood mononuclear cells (PBMCs) and pro-inflammatory cytokines are key factors linking type 2 diabetes and atherosclerosis. We investigated the influence of renal damage on serum, urinary and PBMCs expression behavior of TNF-alpha and IL-6 in these patients.
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