Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption
Author(s) -
Hamish Dobbie,
Robert J. Unwin,
Nuno Faria,
David G. Shirley
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm535
Subject(s) - reabsorption , endocrinology , medicine , renal physiology , excretion , phosphate , extracellular fluid , renal function , fibroblast growth factor 23 , extracellular , kidney , chemistry , calcium , parathyroid hormone , biochemistry
Matrix extracellular phosphoglycoprotein (MEPE), first isolated from tumour-derived tissue from a patient with oncogenic hypophosphataemia, is a putative phosphatonin that has received much less attention than fibroblast growth factor-23. To date, its effect on renal tubular phosphate reabsorption remains undefined.
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