Open AccessBacterial DNA prolongs the survival of inflamed mononuclear cells in haemodialysis patients
Author(s) -
María Dolores Navarro,
Julia Carracedo,
Rafael Ramı́rez,
Juan Antonio Cañas Madueño,
Ana Merino,
Mariano Rodríguez,
Alejandro MartínMalo,
Pedro Aljama
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm414
Subject(s) - medicine , peripheral blood mononuclear cell , kidney disease , immune system , inflammation , hemodialysis , monocyte , apoptosis , immunology , dialysis , biology , in vitro , biochemistry
Chronic kidney disease (CKD) patients show evidence of chronic inflammation with mononuclear cell activation which is mainly caused by uraemia itself and is exacerbated by haemodialysis. Small fragments of bacterial DNA (DNAb) are ubiquitous contaminants, which are capable of passing through dialyser membranes causing the stimulation of cells of the immune system. The aim of this study was to evaluate whether DNAb contamination may have an effect on apoptosis of activated monocytes from CKD-5 patients.
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