Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease | Zendy

Michiel G.H. Betjes | Zendy; Nicolle H. R. Litjens | Zendy; Robert Zietse | Zendy

Open Access

Seropositivity for cytomegalovirus in patients with end-stage renal disease is strongly associated with atherosclerotic disease

Author(s) -

Michiel G.H. Betjes,

Nicolle H. R. Litjens,

Robert Zietse

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm348

Subject(s) - medicine , end stage renal disease , disease , odds ratio , risk factor , gastroenterology , cytomegalovirus , transplantation , retrospective cohort study , kidney disease , logistic regression , immunology , viral disease , herpesviridae , virus

Infection with cytomegalovirus (CMV) is considered a risk factor for progression of atherosclerotic disease. Patients with end-stage renal disease (ESRD) display signs of frequent CMV re-activation, which may be caused by the uraemia-associated defect in cellular immunity. The possible contribution of CMV seropositivity to the hugely increased risk for cardiovascular disease in patients with ESRD is not clear.

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