Open AccessPyridoxal phosphate prevents progression of diabetic nephropathy
Author(s) -
Sho Nakamura,
H. Li,
Ayinuer Adijiang,
Monika Pischetsrieder,
Toshimitsu Niwa
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm166
Subject(s) - endocrinology , medicine , diabetic nephropathy , glycation , pyridoxamine , nephropathy , fibronectin , albuminuria , kidney , diabetes mellitus , vitamin , chemistry , biochemistry , extracellular matrix , vitamin b6
We have demonstrated that pyridoxal 5'-phosphate (PLP), an active form of vitamin B6, inhibits formation of advanced glycation end-products (AGEs) by trapping 3-deoxyglucosone. The present study aimed to clarify if PLP could exert beneficial effects on nephropathy in diabetic rats.
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