Review on uraemic solutes II Variability in reported concentrations: causes and consequences | Zendy

Raymond Vanholder | Zendy; N. Meert | Zendy; Eva Schepers | Zendy; Griet Glorieux | Zendy; Àngel Argilés | Zendy; Philippe Brunet | Zendy; Gerald Cohen | Zendy; Tilman B. Drüeke | Zendy; Harald Mischak | Zendy; Goce Spasovski | Zendy; Ziad A. Massy | Zendy; Joachim Jankowski | Zendy

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Review on uraemic solutes II Variability in reported concentrations: causes and consequences

Author(s) -

Raymond Vanholder,

N. Meert,

Eva Schepers,

Griet Glorieux,

Àngel Argilés,

Philippe Brunet,

Gerald Cohen,

Tilman B. Drüeke,

Harald Mischak,

Goce Spasovski,

Ziad A. Massy,

Joachim Jankowski

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfm151

Subject(s) - medicine , outlier , constructive , intensive care medicine , statistics , process (computing) , computer science , mathematics , operating system

The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; these deviations, if not perceived or handled appropriately, may lead to incorrect interpretations of the pathophysiological role of uraemic solutes and/or to erroneous therapeutic decisions. To come to an objective approach towards this problem, variability analysis of reported concentrations may be of help. Striking outliers should either be discarded or considered together with other values which are more consistent with the majority of reported data.

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