Steroid-resistant idiopathic childhood nephrosis: overdiagnosed and undertreated
Author(s) -
J. H. H. Ehrich,
C.J.C. Geerlings,
Miroslav Živičnjak,
Doris Franke,
Heinz Geerlings,
Jutta Gellermann
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm092
Subject(s) - medicine , nephrosis , nephrotic syndrome , prednisolone , focal segmental glomerulosclerosis , gastroenterology , methylprednisolone , ciclosporin , urology , surgery , glomerulonephritis , chemotherapy , kidney
The rate of complete remission after induction therapy for steroid-resistant nephrotic syndrome (SRNS) due to either focal segmental glomerulosclerosis (FSGS) or minimal change nephrotic syndrome (MCNS) has been reported to be <50%. The present retrospective study investigated 86 children with SRNS due to FSGS and MCNS and found improved rates of complete remission in children with idiopathic FSGS and MCNS after combination therapies using ciclosporin A (CSA) and prednisolone (PRED).
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