Enoxaparin but not unfractionated heparin causes a dose-dependent increase in plasma TGF- 1 during haemodialysis: a cross-over study
Author(s) -
Beata Naumnik,
Jacek Borawski,
Krystyna Pawlak,
Małgorzata Myśliwiec
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm082
Subject(s) - medicine , heparin , hemodialysis , bolus (digestion) , dialysis , platelet , platelet factor 4 , growth factor , endocrinology , urology , receptor
Transforming growth factor-beta1 (TGF-beta1) is a multi-functional cytokine that presents as a mediator of the heparin's pleiotropic action. In this cross-over study, we compared the effects of enoxaparin and unfractionated heparin (UFH) used as anticoagulants during haemodialysis (HD) on plasma TGF-beta1 levels and some platelet activation markers: platelet-derived growth factor-AB (PDGF-AB), beta-thromboglobulin (beta-TG) and platelet factor-4 (PF-4).
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