Open AccessFasting insulin modifies the relation between age and renal function
Author(s) -
Leendert H. Oterdoom,
Aiko P. J. de Vries,
R. T. Gansevoort,
Paul E. de Jong,
Rijk O. B. Gans,
S. J. L. Bakker,
for the PREVEND Study Group
Publication year - 2007
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfm037
Subject(s) - medicine , renal function , endocrinology , insulin , population , insulin resistance , concomitant , creatinine , diabetes mellitus , environmental health
The worldwide increase in end-stage renal disease has been alleged to be associated with insulin resistance-related conditions. Insulin resistance and the concomitant compensatory hyperinsulinaemia may accelerate age-related decline in renal function through inducing glomerular hyperfiltration, even in non-diabetic subjects. This population-based study is the first to investigate whether fasting insulin concentrations modify the relationship between age and renal function in a general non-diabetic population.
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