Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury | Zendy

Charles L. Edelstein | Zendy; Thomas S. Hoke | Zendy; H. Somerset | Zendy; WenFeng Fang | Zendy; Christiaan Klein | Zendy; C A Dinarello | Zendy; Sarah Faubel | Zendy

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Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury

Author(s) -

Charles L. Edelstein,

Thomas S. Hoke,

H. Somerset,

WenFeng Fang,

Christiaan Klein,

C A Dinarello,

Sarah Faubel

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl775

Subject(s) - medicine , hypoxia (environmental) , microbiology and biotechnology , membrane , caspase , apoptosis , pharmacology , biophysics , biochemistry , programmed cell death , oxygen , biology , chemistry , organic chemistry

Caspase-1 is a proinflammatory caspase via activation of the cytokine IL-18. We have recently demonstrated that the caspase-1-mediated production of IL-18 plays a deleterious role in ischaemic acute renal failure (ARF) which is independent of neutrophils and CD4+ T cells. The role of caspase-1 in hypoxia-induced membrane injury of proximal tubules (PT) in vitro is unknown.

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