A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans | Zendy

B. I. Freedman | Zendy; Andrew A. Hicks | Zendy; Michèle M. Sale | Zendy; Eric D. Pierson | Zendy; Carl D. Langefeld | Zendy; Stephen S. Rich | Zendy; Jian Xu | Zendy; Caitrin W. McDonough | Zendy; Bart Janssen | Zendy; Benito A. Yard | Zendy; Fokko J. van der Woude | Zendy; Donald W. Bowden | Zendy

Open Access

A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans

Author(s) -

B. I. Freedman,

Andrew A. Hicks,

Michèle M. Sale,

Eric D. Pierson,

Carl D. Langefeld,

Stephen S. Rich,

Jian Xu,

Caitrin W. McDonough,

Bart Janssen,

Benito A. Yard,

Fokko J. van der Woude,

Donald W. Bowden

Publication year - 2007

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl717

Subject(s) - medicine , locus (genetics) , genetics , gene , end stage renal disease , exon , diabetes mellitus , diabetic nephropathy , chromosome , disease , endocrinology , biology

Four linkage analyses have identified a region on chromosome 18q22-23 that appears to harbour a diabetic nephropathy (DN) susceptibility locus. A trinucleotide repeat sequence in exon 2 of the carnosinase gene (CNDP1) residing on 18q22.3 was subsequently associated with DN in European Caucasians and Arabs.

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