Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes | Zendy

Joyce Geelen | Zendy; Thea J. A. M. van der Velden | Zendy; D. Maroeska W. M. te Loo | Zendy; O.C. Boerman | Zendy; Lambertus P. van den Heuvel | Zendy; L.A.H. Monnens | Zendy

Open Access

Lack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes

Author(s) -

Joyce Geelen,

Thea J. A. M. van der Velden,

D. Maroeska W. M. te Loo,

O.C. Boerman,

Lambertus P. van den Heuvel,

L.A.H. Monnens

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl688

Subject(s) - shiga toxin , verocytotoxin , shiga like toxin , antibody , toxin , microbiology and biotechnology , medicine , pathogenesis , in vivo , escherichia coli , immunology , biology , enterobacteriaceae , biochemistry , gene

After gastrointestinal infection with Shiga-like toxin (Stx) producing Escherichia coli, the toxin is transported from the intestine to the renal microvascular endothelium. This is the main target for Stx in humans. Previous studies indicated that polymorphonuclear leucocytes (PMN) could serve as carriers for Stx in the systemic circulation. As at a later stage we could not confirm these data, we performed new studies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research