Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches | Zendy

Jeroen H. Gerrits | Zendy; J. van de Wetering | Zendy; Stacy Postma | Zendy; J.J.M. Drabbels | Zendy; L. M. B. Vaessen | Zendy; Jan N.M. IJzermans | Zendy; J. Rischen | Zendy; Frans H.J. Claas | Zendy; W Weimar | Zendy; Nicole M. van Besouw | Zendy

Open Access

Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches

Author(s) -

Jeroen H. Gerrits,

J. van de Wetering,

Stacy Postma,

J.J.M. Drabbels,

L. M. B. Vaessen,

Jan N.M. IJzermans,

J. Rischen,

Frans H.J. Claas,

W Weimar,

Nicole M. van Besouw

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl678

Subject(s) - immunosuppression , medicine , human leukocyte antigen , azathioprine , immunology , histocompatibility , minor histocompatibility antigen , histocompatibility testing , antigen , kidney transplantation , kidney transplant , kidney , regimen , major histocompatibility complex , disease

Human leukocyte antigen (HLA)-identical living-related (LR) kidney transplant recipients often receive the standard regimen of immunosuppression. We wondered whether these patients should be exposed to the side effects of these drugs any longer. Safe tapering of immunosuppression should not result in rejection and high donor-directed T-cell responses. In the present study, we investigated the effect of tapering azathioprine (AZA) on T-cell reactivity.

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