ACE2 activity is increased in monocyte-derived macrophages from prehypertensive subjects | Zendy

S Keidar | Zendy; Alexander Strizevsky | Zendy; Ayelet Raz | Zendy; Aviva Gamliel-Lazarovich | Zendy

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ACE2 activity is increased in monocyte-derived macrophages from prehypertensive subjects

Author(s) -

S Keidar,

Alexander Strizevsky,

Ayelet Raz,

Aviva Gamliel-Lazarovich

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl632

Subject(s) - endocrinology , medicine , angiotensin converting enzyme 2 , monocyte , angiotensin ii , renin–angiotensin system , blood pressure , enzyme , biochemistry , chemistry , covid-19 , disease , infectious disease (medical specialty)

Hypertension is a major risk factor for cardiovascular disease and the renin-angiotensin-aldosterone system (RAAS) plays a central pathophysiological role in its formation. Angiotensin-converting enzyme (ACE) and its homologue ACE2 control the formation of counteracting effectors, angiotensin II (AngII), a potent vasopressor and Ang-(1-7) which has vasodilatory action. It is therefore hypothesized that the balance of the activities of these two enzymes, ACE and ACE2, could be important for the control of blood pressure (BP).

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