Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats
Author(s) -
Iddo Z. BenDov,
Orit Pappo,
M. Sklair-Levy,
Hillel Galitzer,
Yaron Ilan,
Tally NavehMany,
J. Silver
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl623
Subject(s) - lanthanum carbonate , medicine , gene expression , endocrinology , gene , pharmacology , biochemistry , kidney disease , hyperphosphatemia , chemistry
Lanthanum (La) carbonate is an effective phosphate-binder, used to reverse hyperphosphataemia due to chronic kidney disease. Some recent studies in rodents have cast safety uncertainties. The aims of this study were to examine the effects of La on parathyroid hormone (PTH) gene expression and hepatic toxicity.
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