P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production | Zendy

Eva Schepers | Zendy; Natalie Meert | Zendy; Griet Glorieux | Zendy; Jan Goeman | Zendy; Johan Van der Eycken | Zendy; R. Vanholder | Zendy

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P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production

Author(s) -

Eva Schepers,

Natalie Meert,

Griet Glorieux,

Jan Goeman,

Johan Van der Eycken,

R. Vanholder

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl584

Subject(s) - metabolite , p cresol , medicine , in vivo , in vitro , uremia , pharmacology , endocrinology , biochemistry , chemistry , biology , microbiology and biotechnology , organic chemistry

Chronic renal insufficiency is associated with the retention of solutes normally excreted by healthy kidneys. P-cresol, a prototype protein-bound uraemic retention solute, has been shown to exert toxic effects in vitro. Recently, however, it has been demonstrated that p-cresol in the human body is conjugated, with p-cresylsulphate as the main metabolite.

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