Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines | Zendy

Christudas Morais | Zendy; Betty Pat | Zendy; Glenda C. Gobé | Zendy; David W. Johnson | Zendy; Helen Healy | Zendy

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Pyrrolidine dithiocarbamate exerts anti-proliferative and pro-apoptotic effects in renal cell carcinoma cell lines

Author(s) -

Christudas Morais,

Betty Pat,

Glenda C. Gobé,

David W. Johnson,

Helen Healy

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl543

Subject(s) - pyrrolidine dithiocarbamate , viability assay , cell culture , apoptosis , microbiology and biotechnology , iκb kinase , iκbα , nf κb , cell growth , cancer research , mtt assay , flow cytometry , biology , medicine , biochemistry , genetics

The activation of nuclear factor-kappaB (NF-kappaB) has been implicated in the development, progression and metastasis of renal cell carcinoma (RCC). This study investigates the effect of pyrrolidine dithiocarbamate (PDTC), a NF-kappaB inhibitor, on two metastatic human RCC cell lines, ACHN and SN12K1.

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