Open AccessPhenotype and genotype: perspectives for peritoneal dialysis patients
Author(s) -
Éric Goffin,
Olivier Devuyst
Publication year - 2006
Publication title -
nephrology, dialysis, transplantation/nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl514
Subject(s) - medicine , peritoneal dialysis , ultrafiltration (renal) , membrane , hemodialysis , dialysis , urology , chromatography , biochemistry , chemistry
Peritonealdialysis(PD)iscurrentlyusedon 15%oftheworldwidedialysispopulation.Recentimprovementsinconnectology andantibiotics managementhaveled toadramatic reduction in the rate and consequences ofperitonitis in PD patients. Deterioration of membranepermeability, with modifications in the transport ofsmall solutes across the peritoneal membrane (PM)and loss of ultrafiltration (UF), is the most frequentabnormality in long-term PD patients, and the mainreason for technical failure. A better understanding ofthe mechanisms and determinants of the small solutetransport and UF is now essential to achieve long-termpreservation of the PM together with improvementsin patient morbidity and mortality.The transport of solutes and water across the PMoccurs through three types of pores located in the capillaryendothelium [1]. The ‘small pores’ (radius 40–50A˚), whichcorrespond to the clefts located between endothelial cells,account for 95% of the hydraulic conductance (UFcoefficient, L