The reverse epidemiology of plasma total homocysteine as a mortality risk factor is related to the impact of wasting and inflammation | Zendy

Mohamed Suliman | Zendy; Peter Stenvinkel | Zendy; Abdul Rashid Qureshi | Zendy; Kamyar KalantarZadeh | Zendy; Peter Bárány | Zendy; Olof Heimbürger | Zendy; Edward F. Vonesh | Zendy; Bengt Lindholm | Zendy

Open Access

The reverse epidemiology of plasma total homocysteine as a mortality risk factor is related to the impact of wasting and inflammation

Author(s) -

Mohamed Suliman,

Peter Stenvinkel,

Abdul Rashid Qureshi,

Kamyar KalantarZadeh,

Peter Bárány,

Olof Heimbürger,

Edward F. Vonesh,

Bengt Lindholm

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl510

Subject(s) - medicine , homocysteine , renal function , wasting , creatinine , diabetes mellitus , dialysis , body mass index , gastroenterology , confounding , end stage renal disease , kidney disease , hemodialysis , c reactive protein , proportional hazards model , inflammation , systemic inflammation , endocrinology

The reason(s) for the apparently paradoxical 'reverse' association in end-stage renal disease (ESRD) patients in whom a low, rather than a high, total plasma total homocysteine (tHcy) level is an indicator of poor outcome remains unclear. The aim of this study was to examine whether the inverse association maintains, mitigates or reverses after comprehensive multivariate adjustment for the presence of wasting and inflammation as well as other potential confounders.

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