Circulating antibodies to nephrin in patients with type 1 diabetes | Zendy

Petri Aaltonen | Zendy; J. Rinta-Valkama | Zendy; Anu Pätäri | Zendy; Päivi Tossavainen | Zendy; Tuula Palmén | Zendy; Petri Kulmala | Zendy; Mikael Knip | Zendy; H. Holthofer | Zendy

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Circulating antibodies to nephrin in patients with type 1 diabetes

Author(s) -

Petri Aaltonen,

J. Rinta-Valkama,

Anu Pätäri,

Päivi Tossavainen,

Tuula Palmén,

Petri Kulmala,

Mikael Knip,

H. Holthofer

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl486

Subject(s) - autoantibody , nephrin , medicine , type 1 diabetes , proteinuria , islet , antibody , diabetes mellitus , antigen , pathogenesis , endocrinology , immunology , kidney , podocyte

Patients with type 1 diabetes typically develop autoantibodies to antigens of the pancreatic islet cells including insulin, glutamic acid decarboxylase and the protein tyrosine phosphatase-related islet antigen 2 protein. Nephrin is a protein shared by the kidney glomeruli, pancreatic beta-cells and islet microendothelia. Since circulating antibodies to nephrin have been shown to cause proteinuria, we wanted to test whether such autoantibodies can be detected in diabetic patients.

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