Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF- 1 overexpression in 5/6 nephrectomized rats | Zendy

Pablo Bautista-García | Zendy; Laura Gabriela SánchezLozada | Zendy; Magdalena Cristóbal-García | Zendy; Edilia Tapia | Zendy; V. Soto | Zendy; Ma. C. Avila-Casado | Zendy; Ricardo Márquez-Velasco | Zendy; Rafael Bojalil | Zendy; Martha Franco | Zendy; Jaime Herrera-Acosta | Zendy

Open Access

Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF- 1 overexpression in 5/6 nephrectomized rats

Author(s) -

Pablo Bautista-García,

Laura Gabriela SánchezLozada,

Magdalena Cristóbal-García,

Edilia Tapia,

V. Soto,

Ma. C. Avila-Casado,

Ricardo Márquez-Velasco,

Rafael Bojalil,

Martha Franco,

Jaime Herrera-Acosta

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl444

Subject(s) - medicine , fibrosis , nitric oxide synthase , proteinuria , endocrinology , creatinine , kidney , transforming growth factor , western blot , nitric oxide , chemistry , biochemistry , gene

Chronic renal damage is associated with inflammatory infiltration, fibrosis and vascular lesion, coupled with increased expression of cyclo-oxygenase 2 (COX-2) and transforming growth factor-beta1 (TGF-beta1). However, the role of inducible nitric oxide synthase (NOS-2) is still controversial. Thus, we studied the contribution of NOS-2 to the expression levels of COX-2 and TGF-beta1, as well as the structural renal injury in rats with subtotal renal ablation (5/6 Nx).

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