Low albumin levels increase endothelial NO production and decrease vascular NO sensitivity | Zendy

Lonneke M. Bevers | Zendy; Ernst E. van Faassen | Zendy; Thi Danh Vuong | Zendy; Zhenmin Ni | Zendy; Pieter Boer | Zendy; H A Koomans | Zendy; Branko Braam | Zendy; N.D. Vaziri | Zendy; Jaap A. Joles | Zendy

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Low albumin levels increase endothelial NO production and decrease vascular NO sensitivity

Author(s) -

Lonneke M. Bevers,

Ernst E. van Faassen,

Thi Danh Vuong,

Zhenmin Ni,

Pieter Boer,

H A Koomans,

Branko Braam,

N.D. Vaziri,

Jaap A. Joles

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl443

Subject(s) - enos , medicine , endocrinology , endothelium , albumin , nitric oxide , endothelial dysfunction , in vivo , vasodilation , ex vivo , nitric oxide synthase type iii , asymmetric dimethylarginine , arginine , nitric oxide synthase , chemistry , biochemistry , biology , microbiology and biotechnology , amino acid

Hypoalbuminaemia is associated with increased risk of cardiovascular disease. It is unclear whether endothelial dysfunction is a direct result of low albumin or whether it is caused by factors like chronic inflammation or dyslipidaemia. In this study, the effect of low albumin concentrations on endothelial nitric oxide synthase (eNOS)-dependent NO production was determined in vitro and ex vivo.

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