Open AccessTAK-603, an anti-inflammatory compound, reduces crescentic glomerulonephritis and preserves renal function in WKY rats
Author(s) -
Junya Yamahana,
Takashi Wada,
Kengo Furuichi,
Norihiko Sakai,
Hitoshi Yokoyama,
Shuichi Kaneko
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl431
Subject(s) - medicine , glomerulonephritis , renal function , function (biology) , kidney , microbiology and biotechnology , biology
The therapeutic efficacy of the regulation of T helper (Th)-1-predominant immune responses remains to be investigated. Therefore, the effects of the anti-inflammatory compound TAK-603 were investigated in a model of crescentic glomerulonephritis induced by a small dose of nephrotoxic serum in Wistar-Kyoto rats.
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