Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice | Zendy

Shuichi Tsuruoka | Zendy; Kenta Nishiki | Zendy; Takashi Ioka | Zendy; Hitoshi Ando | Zendy; Yuichiro Saito | Zendy; Masahiko Kurabayashi | Zendy; Ryozo Nagai | Zendy; Akio Fujimura | Zendy

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Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice

Author(s) -

Shuichi Tsuruoka,

Kenta Nishiki,

Takashi Ioka,

Hitoshi Ando,

Yuichiro Saito,

Masahiko Kurabayashi,

Ryozo Nagai,

Akio Fujimura

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl335

Subject(s) - parathyroid hormone , klotho , endocrinology , medicine , urinary system , calcium , creatinine , urinary calcium , excretion , hormone , phenotype , calcium metabolism , kidney , biology , biochemistry , gene

Homozygous Klotho mutant mice (KL(-/-) mice) exhibit multiple phenotypes resembling human ageing. Increases in the ratio of urinary calcium to urinary creatinine (uCa/uCr) and in serum Ca concentration and decreases in urinary Cr excretion and serum parathyroid hormone (PTH) concentration were reported; however, precise information about renal Ca handling was not reported in these animals.

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