Open AccessEffect of tranilast in early-stage diabetic nephropathy
Author(s) -
Jun Soma,
Kôzô Satô,
Harutaka Saito,
Y. Tsuchiya
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl325
Subject(s) - medicine , excretion , diabetic nephropathy , creatinine , endocrinology , tranilast , renal function , nephropathy , diabetes mellitus , urology
Tranilast is an antifibrotic drug known to suppress collagen synthesis by fibroblasts by interfering with the effects of TGF-beta. We recently reported that it slowed the progression rate of advanced diabetic nephropathy (DN) by reducing the accumulation of collagens in renal tissue. The present study was undertaken to examine the effect of tranilast on early-stage DN.
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