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Stable graft function after reduction of calcineurin inhibitor dosage in paediatric kidney transplant patients
Author(s) -
Christian Plank,
Kerstin Benz,
Kerstin Amann,
KaiDietrich Nüsken,
Katalin Dittrich,
Wolfgang Rascher,
Katja Sauerstein,
Anja Stuppy,
B. Klare,
Jörg Dötsch
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl279
Subject(s) - calcineurin , medicine , chronic allograft nephropathy , toxicity , urology , kidney disease , reduction (mathematics) , renal function , tacrolimus , kidney , kidney transplantation , transplantation , geometry , mathematics
Chronic calcineurin inhibitor (CNI) toxicity contributes to the development and progression of chronic allograft nephropathy (CAN), which is still the major cause of transplant dysfunction and graft loss. Reduction in dosage of CNI may delay the development of CAN, leading to longer graft survival.

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