Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition | Zendy

Naofumi Imai | Zendy; Shinichi Nishi | Zendy; Bassam Alchi | Zendy; Mitsuhiro Ueno | Zendy; Sachiko Fukase | Zendy; Masaaki Arakawa | Zendy; Kazuhide Saito | Zendy; Kota Takahashi | Zendy; Fumitake Gejyo | Zendy

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Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition

Author(s) -

Naofumi Imai,

Shinichi Nishi,

Bassam Alchi,

Mitsuhiro Ueno,

Sachiko Fukase,

Masaaki Arakawa,

Kazuhide Saito,

Kota Takahashi,

Fumitake Gejyo

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl210

Subject(s) - complement system , lectin pathway , abo blood group system , lectin , peritubular capillaries , kidney , mannan binding lectin , alternative complement pathway , classical complement pathway , ficolin , immunology , medicine , microbiology and biotechnology , pathology , antibody , biology

Complement 4d (C4d) deposition in the peritubular capillary (PTC) in the kidney allograft is a useful diagnostic marker for humoral rejection. C4d is produced not only by the classical pathway but also by the lectin pathway of the complement activation cascade. We have recently reported the in situ role of the later phase of the complement cascade in renal allografts with C4d deposition; however, the initial process prior to C4d deposition is yet to be resolved.

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