Protective role of l-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury | Zendy

Sik Lee | Zendy; Sang-Ok Moon | Zendy; Won Kim | Zendy; Mi Jeong Sung | Zendy; Duk Hoon Kim | Zendy; Kyung Pyo Kang | Zendy; Yong Bum Jang | Zendy; Jung Eun Lee | Zendy; Kyu Yun Jang | Zendy; Sang Yong Lee | Zendy; Sung Kwang Park | Zendy

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Protective role of l-2-oxothiazolidine-4-carboxylic acid in cisplatin-induced renal injury

Author(s) -

Sik Lee,

Sang-Ok Moon,

Won Kim,

Mi Jeong Sung,

Duk Hoon Kim,

Kyung Pyo Kang,

Yong Bum Jang,

Jung Eun Lee,

Kyu Yun Jang,

Sang Yong Lee,

Sung Kwang Park

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl209

Subject(s) - medicine , cisplatin , renal injury , pharmacology , kidney , chemotherapy

Oxidative stress and inflammation are implicated in the pathogenesis of cisplatin-induced nephrotoxicity. l-2-oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrug, and increases cellular glutathione (GSH). OTC is converted to cysteine by the intracellular enzyme, oxoprolinase. To date, the protective role of OTC on cisplatin-induced renal injury has not been investigated. The purpose of the present study was to examine the protective effect of OTC on cisplatin-induced renal injury and to examine the mechanism of its protection.

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