Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces | Zendy

Robert M. Q. Shanks | Zendy; Jennifer L. Sargent | Zendy; Raquel Martínez | Zendy; Martha L. Graber | Zendy; George A. O’Toole | Zendy

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Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces

Author(s) -

Robert M. Q. Shanks,

Jennifer L. Sargent,

Raquel Martínez,

Martha L. Graber,

George A. O’Toole

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl170

Subject(s) - biofilm , staphylococcus aureus , microbiology and biotechnology , heparin , medicine , sodium citrate , staphylococcus epidermidis , gentamicin , sodium , catheter , chemistry , bacteria , surgery , biology , antibiotics , pathology , genetics , organic chemistry

Microbial biofilms form on central venous catheters and may be associated with systemic infections as well as decreased dialysis efficiency due to catheter thrombosis. The most widely used anticoagulant catheter lock solution in the US is sodium heparin. We have previously shown that sodium heparin in clinically relevant concentrations enhances Staphylococcus aureus biofilm formation. In the present study, we examine the effect of several alternative catheter lock solutions on in vitro biofilm formation by laboratory and clinical isolates of S. aureus and coagulase-negative staphylococci (CNS).

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