Early markers of inflammation in a high angiotensin II state—results of studies in Bartter's/Gitelman's syndromes | Zendy

Paul A. Davis | Zendy; Michele Mussap | Zendy; Elisa Pagnin | Zendy; L. Bertipaglia | Zendy; Vincenzo Savica | Zendy; Andrea Semplicini | Zendy; Lorenzo A. Calò | Zendy

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Early markers of inflammation in a high angiotensin II state—results of studies in Bartter's/Gitelman's syndromes

Author(s) -

Paul A. Davis,

Michele Mussap,

Elisa Pagnin,

L. Bertipaglia,

Vincenzo Savica,

Andrea Semplicini,

Lorenzo A. Calò

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl112

Subject(s) - inflammation , medicine , endocrinology , tumor necrosis factor alpha , angiotensin ii , serum amyloid a , renin–angiotensin system , cytokine , receptor , blood pressure

Inflammation has been increasingly recognized as playing a critical role in hypertension and atherosclerosis as reflected by overexpression and increased production of a variety of pro-inflammatory mediators. As angiotensin II (Ang II) also plays a major role in these diseases, the relationship between inflammation and Ang II has drawn increasing scrutiny. This study explores Ang II effects in Bartter's and Gitelman's syndromes (BS/GS) which do not develop hypertension and related cardiovascular remodelling and atherosclerosis, in spite of high Ang II levels and activation of the renin-angiotensin-aldosterone system while the NO system is up-regulated.

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