Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitis | Zendy

Smaragdi Marinaki | Zendy; AnnaIsabelle Kälsch | Zendy; Peter Grimminger | Zendy; Annette Breedijk | Zendy; Rainer Birck | Zendy; Wilhelm H. Schmitt | Zendy; Christel Weiß | Zendy; Fokko J. van der Woude | Zendy; Benito A. Yard | Zendy

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Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitis

Author(s) -

Smaragdi Marinaki,

AnnaIsabelle Kälsch,

Peter Grimminger,

Annette Breedijk,

Rainer Birck,

Wilhelm H. Schmitt,

Christel Weiß,

Fokko J. van der Woude,

Benito A. Yard

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl097

Subject(s) - medicine , microscopic polyangiitis , systemic vasculitis , vasculitis , gastroenterology , autoantibody , population , cyclophosphamide , univariate analysis , immunology , disease , chemotherapy , multivariate analysis , antibody , environmental health

Although in antineutrophil cytoplasmic autoantibodies (ANCA)-associated systemic vasculitis (AASV) patients, activation of T-cells has been described, persistence of these alterations has not been well characterized. This study was conducted to define persistent T-cell activation (PTA) in AASV patients and to assess whether this correlates with disease activity, disease severity, age or therapy.

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