Gene profiling of polycystic kidneys | Zendy

Gisela Schieren | Zendy; Brigitta Rumberger | Zendy; Marinella Klein | Zendy; Clemens Kreutz | Zendy; Jochen Wilpert | Zendy; Marcel Geyer | Zendy; Daniel Faller | Zendy; Jens Timmer | Zendy; Ivo Quack | Zendy; Lars Christian Rump | Zendy; Gerd Walz | Zendy; Johannes Donauer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Gene profiling of polycystic kidneys

Author(s) -

Gisela Schieren,

Brigitta Rumberger,

Marinella Klein,

Clemens Kreutz,

Jochen Wilpert,

Marcel Geyer,

Daniel Faller,

Jens Timmer,

Ivo Quack,

Lars Christian Rump,

Gerd Walz,

Johannes Donauer

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl071

Subject(s) - autosomal dominant polycystic kidney disease , medicine , pathogenesis , polycystic kidney disease , cyst , extracellular matrix , pathology , secretion , kidney , apoptosis , kidney disease , microbiology and biotechnology , endocrinology , disease , genetics , biology

While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increased apoptosis and proliferation rates have been implicated in cystogenesis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research