Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes | Zendy

Eun Young Lee | Zendy; Choon Hee Chung | Zendy; JungHyun Kim | Zendy; Hea-Jung Joung | Zendy; SaeYong Hong | Zendy

Open Access

Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes

Author(s) -

Eun Young Lee,

Choon Hee Chung,

JungHyun Kim,

Hea-Jung Joung,

SaeYong Hong

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl022

Subject(s) - podocyte , medicine , diabetic nephropathy , pathogenesis , reactive oxygen species , vascular endothelial growth factor , diabetes mellitus , nephropathy , downregulation and upregulation , endocrinology , cancer research , microbiology and biotechnology , kidney , vegf receptors , proteinuria , biology , biochemistry , gene

The increased production of reactive oxygen species (ROS) may be involved in the onset or development of diabetic vascular complications. The release of ROS from podocytes plays a role in the pathogenesis of glomerular damage in various experimental glomerular diseases. Although it is assumed that the podocyte injury also plays an important role in diabetic nephropathy, the mechanism is still unknown.

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