Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-β1 dependent and TGF-β1 independent pathways | Zendy

Susan Yung | Zendy; Candice Y. Y. Lee | Zendy; Qing Zhang | Zendy; Shuk Kei Lau | Zendy; Ryan Tsang | Zendy; Tak Mao Chan | Zendy

Open Access

Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-β1 dependent and TGF-β1 independent pathways

Author(s) -

Susan Yung,

Candice Y. Y. Lee,

Qing Zhang,

Shuk Kei Lau,

Ryan Tsang,

Tak Mao Chan

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl017

Subject(s) - thrombospondin 1 , fibronectin , transforming growth factor , thrombospondin , medicine , endocrinology , kidney , viral matrix protein , extracellular matrix , microbiology and biotechnology , biology , immunology , matrix metalloproteinase , angiogenesis , virus , metalloproteinase

TGF-beta1 bioactivation, consequent to the interaction of latent TGF-beta1 with thrombospondin-1 (TSP-1), correlates with matrix accumulation in mesangial cells. Tubulointerstitial damage predicts poor renal survival. There is little data on TGF-beta1 bioactivation and matrix synthesis in human proximal renal tubular epithelial cells under the influence of high glucose concentrations. This study thus investigates the role of TSP-1 in mediating elevated glucose-induction of TGF-beta1 bioactivation and fibronectin (FN) synthesis in human proximal tubular epithelial cells.

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