Increased expression of monocytic angiotensin-converting enzyme in dialysis patients with cardiovascular disease | Zendy

Christof Ulrich | Zendy; Gunnar H. Heine | Zendy; Patric Garcia | Zendy; B Reichart | Zendy; Thomas Georg | Zendy; Matthias Krause | Zendy; Hans Köhler | Zendy; Matthias Girndt | Zendy

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Increased expression of monocytic angiotensin-converting enzyme in dialysis patients with cardiovascular disease

Author(s) -

Christof Ulrich,

Gunnar H. Heine,

Patric Garcia,

B Reichart,

Thomas Georg,

Matthias Krause,

Hans Köhler,

Matthias Girndt

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfl008

Subject(s) - medicine , proinflammatory cytokine , pathogenesis , oxidative stress , inflammation , angiotensin converting enzyme , angiotensin ii , kidney disease , disease , dialysis , renin–angiotensin system , endocrinology , ace inhibitor , enzyme , blood pressure , biochemistry , biology

Patients with chronic renal disease suffer from accelerated atherogenesis, which is promoted by inflammation and oxidative stress. Tissue angiotensin converting enzyme (ACE) exerts proinflammatory and prooxidative effects by producing angiotensin II. Monocytes are strongly involved in the pathogenesis of atherosclerosis. They express ACE, which might contribute to their atherogenic potency. We hypothesize that dialysis patients have increased monocytic ACE expression, and that ACE expression on circulating monocytes is associated with prevalent cardiovascular disease.

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