Respective role of uraemic toxins and myeloperoxidase in the uraemic state
Author(s) -
Chantal CapeillèreBlandin,
Valérie Gausson,
Anh Nguyen,
Béatrice DescampsLatscha,
Tilman B. Drüeke,
Véronique WitkoSarsat
Publication year - 2006
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfl007
Subject(s) - myeloperoxidase , medicine , kidney disease , hydrogen peroxide , nadph oxidase , endocrinology , kidney , hemodialysis , phagocyte , reactive oxygen species , phenol red , renal function , oxidative stress , biochemistry , immunology , chemistry , phagocytosis , inflammation , chromatography
In haemodialysis (HD) patients, advanced oxidation protein products (AOPP) were previously ascribed to oxidized plasma proteins, resulting mainly from increased myeloperoxidase (MPO) activity. The aim of the present study was to assess the mechanisms leading to the generation of AOPP during the course of chronic kidney disease including end-stage renal disease, with particular focus on AOPP and MPO characterization in the plasma at decreasing levels of kidney function.
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