Characteristics of polyclonal anti-human nephrin antibodies induced by genetic immunization using nephrin cDNA | Zendy

Togo Aoyama | Zendy; Kouju Kamata | Zendy; Nozomu Yamanaka | Zendy; Yasuo Takeuchi | Zendy; Masaaki Higashihara | Zendy; Seishi Kato | Zendy

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Characteristics of polyclonal anti-human nephrin antibodies induced by genetic immunization using nephrin cDNA

Author(s) -

Togo Aoyama,

Kouju Kamata,

Nozomu Yamanaka,

Yasuo Takeuchi,

Masaaki Higashihara,

Seishi Kato

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfk101

Subject(s) - nephrin , polyclonal antibodies , complementary dna , microbiology and biotechnology , antibody , western blot , glomerular basement membrane , antigen , biology , podocyte , immunology , gene , glomerulonephritis , biochemistry , endocrinology , proteinuria , kidney

Nephrin is an essential protein for maintaining the normal structure of the podocyte foot process and the glomerular filtration barrier. To analyse the mechanism of proteinuria and treatment of nephrotic syndrome, we produced and characterized polyclonal anti-human nephrin antibodies using a newly developed genetic immunization technique.

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