Apoptosis and proliferation of cultured mesangial cells isolated from kidneys of rosiglitazone-treated pregnant diabetic rats | Zendy

Joshua Weissgarten | Zendy; Sylvia Berman | Zendy; Shai Efrati | Zendy; Micha J. Rapoport | Zendy; Zhan Averbukh | Zendy; Leonid Feldman | Zendy

Open Access

Apoptosis and proliferation of cultured mesangial cells isolated from kidneys of rosiglitazone-treated pregnant diabetic rats

Author(s) -

Joshua Weissgarten,

Sylvia Berman,

Shai Efrati,

Micha J. Rapoport,

Zhan Averbukh,

Leonid Feldman

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfk084

Subject(s) - rosiglitazone , medicine , inflammation , endocrinology , apoptosis , diabetes mellitus , mesangial cell , peroxisome proliferator activated receptor , receptor , context (archaeology) , proinflammatory cytokine , mesangial proliferative glomerulonephritis , kidney , biology , nephropathy , paleontology , biochemistry

The peroxisome proliferator activating nuclear receptors (PPAR) are activated in the context of inflammation, diabetes or normal pregnancy. Renal mesangial cells express PPAR-gamma which upon activation are capable of exerting anti-inflammatory effects. We investigated the effect of in vivo treatment by rosiglitazone on angiotensin II (A-II) stimulated manifestations of inflammation in cultured renal mesangial cells, such as proliferation, apoptosis, TGF-beta1 production and nuclear factor kappaB (NF-kappaB) activation, in the situation of pregnancies, complicated or not with diabetes.

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