Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the development of proteinuria and renal injury in OLETF rats | Zendy

Momoko Ogawa | Zendy; Nobuhito Hirawa | Zendy; Takamasa Tsuchida | Zendy; Naomi Eguchi | Zendy; Yukari Kawabata | Zendy; Atsushi Numabe | Zendy; Hideyuki Negoro | Zendy; Rie HakamadaTaguchi | Zendy; Kousuke Seiki | Zendy; Satoshi Umemura | Zendy; Yoshihiro Urade | Zendy; Yoshio Uehara | Zendy

Open Access

Urinary excretions of lipocalin-type prostaglandin D2 synthase predict the development of proteinuria and renal injury in OLETF rats

Author(s) -

Momoko Ogawa,

Nobuhito Hirawa,

Takamasa Tsuchida,

Naomi Eguchi,

Yukari Kawabata,

Atsushi Numabe,

Hideyuki Negoro,

Rie HakamadaTaguchi,

Kousuke Seiki,

Satoshi Umemura,

Yoshihiro Urade,

Yoshio Uehara

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfk009

Subject(s) - medicine , endocrinology , lipocalin , proteinuria , diabetic nephropathy , urinary system , renal injury , diabetes mellitus , type 2 diabetes , nephropathy , kidney , urology

Otsuka Long-Evans Tokushima Fatty (OLETF) rats genetically develop diabetes which is associated with hypertension. In preliminary studies, urinary excretions of L-PGDS (lipocaline-type prostaglandin D synthase) increase before diabetic nephropathy obviously develops, and this may predict progression of renal injury following diabetes. In the present study, we attempted to define whether urinary excretions of L-PGDS behave as the predictor of development of diabetic nephropathy in OLETF rats.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research