Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism | Zendy

Masahide Mizobuchi | Zendy; Etsuro Ogata | Zendy; Ikuji Hatamura | Zendy; Fumihiko Koiwa | Zendy; Fumie Saji | Zendy; Kazuhiro Shiizaki | Zendy; Shigeo Negi | Zendy; Eriko Kinugasa | Zendy; Akira Ooshima | Zendy; Shozo Koshikawa | Zendy; Tadao Akizawa | Zendy

Open Access

Up-regulation of Cbfa1 and Pit-1 in calcified artery of uraemic rats with severe hyperphosphataemia and secondary hyperparathyroidism

Author(s) -

Masahide Mizobuchi,

Etsuro Ogata,

Ikuji Hatamura,

Fumihiko Koiwa,

Fumie Saji,

Kazuhiro Shiizaki,

Shigeo Negi,

Eriko Kinugasa,

Akira Ooshima,

Shozo Koshikawa,

Tadao Akizawa

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfk008

Subject(s) - medicine , endocrinology , secondary hyperparathyroidism , hyperphosphatemia , kidney disease , hyperparathyroidism , calcification , population , pathogenesis , calcium , parathyroid hormone , environmental health

Cardiovascular disease is the most frequent cause of death in patients with end-stage kidney disease (ESKD). Vascular calcification is a confirmed risk factor for cardiovascular events in the general population and has a high occurrence in patients with ESKD. Despite the high prevalence of vascular calcification in ESKD, the pathogenesis of the disorder is still obscure. The present study examined the expressions of bone-associated factors in calcified arteries in subtotally nephrectomized rats with severe secondary hyperparathyroidism (SHPT).

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