Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli | Zendy

Yuichi Kikuchi | Zendy; Toshihiko Imakiire | Zendy; Toshitake Hyodo | Zendy; Taketoshi Kushiyama | Zendy; Keishi Higashi | Zendy; Naomi Hyodo | Zendy; Shigenobu Suzuki | Zendy; Soichiro Miura | Zendy

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Advanced glycation end-product induces fractalkine gene upregulation in normal rat glomeruli

Author(s) -

Yuichi Kikuchi,

Toshihiko Imakiire,

Toshitake Hyodo,

Taketoshi Kushiyama,

Keishi Higashi,

Naomi Hyodo,

Shigenobu Suzuki,

Soichiro Miura

Publication year - 2005

Publication title -

nephrology dialysis transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi232

Subject(s) - downregulation and upregulation , medicine , glycation , mesangium , streptozotocin , endocrinology , cx3cl1 , diabetes mellitus , advanced glycation end product , chemokine , gene , nephropathy , biology , biochemistry , inflammation , chemokine receptor

We previously reported that fractalkine was upregulated in streptozotocin-induced diabetic kidneys. Fractalkine in diabetic kidneys was detected on glomerular capillaries and the mesangium. This upregulation was suppressed by treatment with angiotensin-converting enzyme inhibitor (ACE-I) or aminoiguanidine. We examined what factors induce fractalkine upregulation in normal rat glomeruli.

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